Brucellosis Vaccines: An Overview
نویسندگان
چکیده
Brucella is ┙-Proteobacteria causing an infectious disease in mammals that could be transmitted to humans. Ruminant and swine are prone to be infected by such microorganism all over the world, thus acting as a potential reservoir for domestic livestock and therefore, affecting humans. Brucella species differ in their hosts’ preference, physiological abilities and cell surface structural characteristics. Those affecting domestic livestock are B. melitensis (sheep and goats), B. abortus (cattle), B. suis (swine), and B. ovis (sheep). Because domestic ruminants and swine are essential to the economy of millions of people, particularly in low income countries, brucellosis is a major cause of direct economical losses and a major impediment for trade. Moreover, human brucellosis is a severe and debilitating disease requiring a prolonged antibiotic treatment and often leaving permanent and disabling sequel. Thus, its control and if it possible its eradication are major goals of public health programs in affected countries (1,2).
منابع مشابه
Stability Study of Iriba Brucellosis Full-dose and Reduced-dose Vaccine Produced by Razi Institute in Iran
Stability study of biological products plays an important role for determination of product changes in maintenance period and ensuring of safety and efficacy of vaccines. In this research, accelerated and long-term stability study performed for six batches of full and reduced-dose cattle Iriba strain brucellosis vaccine that manufactured by Razi vaccine and serum research institute as a new v...
متن کاملA Review of Brucellosis in Iran: Epidemiology, Risk Factors, Diagnosis, Control, and Prevention
Brucellosis caused by species of Brucella is among the most prevalent zoonoses with the annual incidence of half a million cases globally. Most parts of Iran are endemic for brucellosis, and the annual incidence of the human and animal brucellosis is still high. At present, there is no safe and protective human vaccine against brucellosis, and the only preventive strategy is animal vaccination,...
متن کاملAn overview on Leishmania vaccines: A narrative review article
Leishmaniasis is one of the major health problems and categorized as a class I disease (emerging and uncontrolled) by World Health Organization (WHO), causing highly significant morbidity and mortality. Indeed, more than 350 million individuals are at risk of Leishmania infection, and about 1.6 million new cases occur causing more than 50 thousands death annually. Because of the severe...
متن کاملRecent developments in livestock and wildlife brucellosis vaccination.
Live attenuated brucellosis vaccines have been available for protecting domestic livestock against Brucella melitensis and B. abortus for more than 60 years. Current vaccines are effective in preventing abortion and transmission of brucellosis, but poor at preventing infection or seroconversion. In addition, they can induce abortions in pregnant animals and are infectious to humans. It can be a...
متن کاملNanoparticle or conventional adjuvants: which one improves immune response against Brucellosis?
Objective(s): Brucellosis is a common infectious disease among animals and humans. While subunit vaccines could be used as an efficient strategy against pathogens, they usually seem to be less immunogenic than live or killed vaccines. However, the use of a suitable adjuvant accompanied by subunit vaccines can be a good alternative to enhance the immune response.Materials and Methods: To find a ...
متن کامل